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Mauve Factor (Kryptopyrrole)

"Pyroluria," "Pyrroluria," "Pyrolleuria," "Pyrrole Disorder," "Elevated Kryptopyrrole," "B6 Deficiency" and other similar terms are all used to describe variants of the same basic condition: Most commonly called Pyroluria, however the more correct term now is Mauve factor. The root cause is the production of too much "kryptopyrrole" (KP) or "hemepyrrole" in the blood.

Elevated kryptopyrrole levels result from an abnormality in hemoglobin (the protein that holds iron in red blood cells). Kryptopyrrole has no known function in the body, but it is excreted in urine. Pyroluria is a feature of many behavioral and emotional disorders. Its cause is an inborn error in pyrrole chemistry, resulting in a dramatic zinc and vitamin B6 deficiency. Elevated levels of kryptopyrrole produce symptoms including irritability, anger episodes, poor memory, impaired intellectual function, impaired immune function and inability to deal with stress. Patients are easily identified by their inability to tan ("china doll" face), poor dream recall, abnormal fat distribution, and sensitivity to light and sound.

The decisive laboratory test is analysis for kryptopyrroles in urine. Treatment is centered on zinc and vitamin B6 supplements together with omega-6 essential fatty acids. If left undiagnosed and untreated, the condition can lead to a wide range of significant health problems.

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Last modified: 09/01/10