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Scientists Warns 'No-Phenol' Digestive Enzymes 'Dangerous' Autism Treatment Enzymes, amino acids and phenol in autism

[The giving of digestive enzymes that purport to mediate the effects of gluten and casein in the diet of one's autistic child is the current trend du jour in the autism community by many parents. This is readily witnessed by the mercurial rise of enzymes and autism oriented email groups on the Internet, replacing the spot once enjoyed by secretin. Dr. Jon Pangborn is an early creator of such products, now being marketed by Kirkman Labs, Klaire Labs and a newer company, Houston Labs. In a commentary in the current Autism Research Review International, Pangborn issues a warning on the risks of a new "enzyme supplement that destroys all dietary phenols" - the kind recently introduced by Houston Labs, apparently.

Dietary supplements are not government regulated. The consumer relies on a company's reputation, and the word-of-mouth endorsements of other consumers to gauge product safety and efficacy.

So, especially in such an environment of lesser science, dire warnings issued by an industry scientist must be taken seriously, and so this one is presented here.

In an article in the same publication that accompanies this warning entitled "Autism, digestive enzymes, the Internet, and fraud", Dr. Bernard Rimland, founder of the Autism Research Institute and the DAN! Conferences goes into detail on the unseemly underside of this business. Excerpts of that expose appear following this article. Immediately below is the full text of Dr. Pangborn's warning and contains technical language. FEAT has no independent means for evaluating this warning, nor the comments made by Dr. Rimland following. The material is reproduced here without endorsement, as clippings for the readers' information only. -LS]

One purpose for providing special digestive enzymes is to aid the complete breakdown of dietary proteins and peptides into single, free-form amino acids. An objective is to reduce or nearly eliminate harmful peptides that can act as false neurotransmitters and disregulators of immune response. For this objective, both dietary restrictions and enzyme supplementation are advisable.

Free-form amino acids can be easily absorbed and utilized in body tissues. Each then has work to do in the body. The amino acid tyrosine is needed for formation of thyroglobulin, catecholamines hormones (dopamine, noradrenalin), melanin pigment molecules, and other essential metabolites. When tyrosine is deficient, thyroid functions, mood, behavior and attitude can be affected as can rest and sleep patterns and cognitive abilities.

Tyrosine is a phenol; simply stated, it is phenol-alanine (4-hydroxyphenylalanine). While some phenols, such as pentachlorophenol, can inhibit sulfation, other phenol molecules, especially tyrosine, are essential to human life. In this author's opinion, it is absolutely wrong to provide an enzyme supplement that destroys all dietary phenols. A "no-phenol regimen" invites metabolic disorder, especially for individuals who may have problems with tyrosine adequacy.

Many autistics do seem to have a problem in this area. They do not make enough tyrosine from its essential precursor, phenylalanine, and they then depend much more heavily on dietary tyrosine. In fact, individuals with disordered phenylalanine metabolism and deficient tyrosine were among the first to have a metabolic explanation for their autism. A product that destroys the phenol tyrosine is certain to be harmful or dangerous to such individuals. I emphatically urge that any such product not be used for human consumption.

-Jon Pangborn, Ph.D., F.A.I.C.

 

 

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This website has no financial connection to the supplement or health products industry.

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Last modified: 12/13/10

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