ALL NATURAL ADVANTAGE

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The first report of stimulant use to treat ADHD was in 1937.   The action of methylphenidate (Ritalin) is virtually identical with cocaine.  It acts on the CNS with a dopamine-agonistic effect that is slower in onset, but mechanistically almost identical to cocaine and amphetamines.

Methylphenidate binds to the dopamine transporter and increases dopamine levels in the brain. This is similar in its mechanism to cocaine, but the euphoric effects and addictive potential of cocaine occur because it is administered in ways that result in a very rapid increase in blood levels, with about 60% of dopamine transporters blocked. In contrast, methylphenidate remains bound to the dopamine transporter for several hours; therefore, repeated doses have very little effect. When methylphenidate is administered by mouth at a standard clinical dose, euphoric effects are not present. Although most patients respond well to psychostimulants, a small group has atypical responses or are at increased risk of undesirable side effects.

 The adverse reactions related to methylphenidate (Ritalin) use include:

The FDA is aware that children have died after taking the drug Adderall, but cannot tell whether the rate is higher in these children than it is in the general population. 20 people taking the drug, including 12 children, had suddenly died between 1999 and 2003. Seven sudden deaths of children taking other ADHD stimulants including Concerta, sold by Johnson & Johnson and Ritalin, made by Novartis AG have been reported. US Plans to Update Attention Deficit Drugs Labels http://www.medscape.com/viewarticle/507603?src=mp

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Last modified: 05/28/08